Calcium D-Glucarate
- Safely removes "dirty" estrogens from reabsorption
- Reduces symptoms of Estrogen Dominance
- Capsule, 60 servings (2-month supply)
Estrogen needs to be cleared from the body in three steps.
Step 1: DIM frees oxidized estrogens in Phase I and the estrogens are passed on to Phase II liver detoxification.
Step 2: Toxins (including "dirty" estrogens) get passed on to the sulfation pathway where they are neutralized. Sulforaphane (Brocco Power) plays a role here.
Step 3: Toxins (including "dirty" estrogens) get passed on to the glucuronidation pathway where they are bound up by glucaric acid (Calcium D-Glucarate) and then fully eliminated from the body.
To graphically explain where DIM, Sulforaphane, and Calcium d-Glucarate play a role in your body, think of a clogged toilet that consists of a toilet bowl and a drain.
With DIM, you have just unclogged your toilet bowl but not the drain. DIM can open the toilet bowl but it's the sulforaphane (and Calcium d-Glucarate) that opens the drain.
2 capsules per day, before or after meals. Take away from Rx medications.
Calcium as Calcium D-Glucarate
Other Ingredients: Hypromellose Capsule, Ascorbyl Palmitate
Heerdt AS, et al. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci 1995;31:101-5.
Abou-issa H, et al. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995;15:805-10.
Walaszek Z, et al. Metabolism, uptake, and excretion of a d-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prevent 1997;21:178-90.
Yoshimi N, et al. Inhibition of azoxymethane-induced rat colon carcinogenesis by potassium hydrogen D-glucarate. Int J Oncol 2000;16:43-8.
Singh J, Gupta KP. Calcium glucarate prevents tumor formation in mouse skin. Biomed Environ Sci 2003 Mar;16(1):9-16.
Wargovich MJ, Jimenez A, McKee K, et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis. Jun 2000;21(6):1149-1155.
Hanausek M, Walaszek Z, Szemraj J, et al. Modulation of biomarkers during chemoprevention of mouse lung tumorigenesis by D-glucarate. Chest. May 2004;125(5 Suppl):149s.
Lajolo C, Sgambato A, Maiorano E, et al. Calcium glucarate inhibits DMBA-induced oral carcinogenesis in the hamster: histomorphometric evaluation. Anticancer Res. Mar 2010;30(3):843-849."
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